施一公

个人简介

     施一公，1985年保送进入清华大学生物科学与技术系，1989年提前一年毕业，获学士学位；1995年获美国约翰霍普金斯大学医学院分子生物物理博士学位，随后在美国纪念斯隆-凯特琳癌症中心进行博士后研究；1998—2008年历任美国普林斯顿大学分子生物学系助理教授、副教授、教授、Warner-Lambert/Parke-Davis讲席教授。2008年全职回到清华大学工作，曾任清华大学副校长、生命科学与医学研究院院长。2018年至今，担任西湖大学讲席教授、校长。

研究方向

     主要运用结构生物学、生物化学和生物物理手段研究细胞凋亡的分子机制、重要膜蛋白以及细胞内生物大分子机器的结构与功能。

代表论文

1. Rui Bai, Ruixue Wan*, Lin Wang, Kui Xu, Qiangfeng Zhang, Jianlin Lei, Yigong Shi* (2021). Structure of the activated human minor spliceosome. Science, 371(6535): eabg0879. (*co-corresponding authors) 

2. Guanghui Yang, Rui Zhou, Xuefei Guo, Chuangye Yan, Jianlin Lei, Yigong Shi (2020). Structural basis of γ-secretase inhibition and modulation by small molecule drugs. Cell, 184(2): 521-533.

3. Rui Bai, Ruixue Wan*, Chuangye Yan, Qi Jia, Jianlin Lei, Yigong Shi* (2020). Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371(6525): eabe8863. (*co-corresponding authors)

4. Ruixue Wan, Rui Bai, Chuangye Yan, Jianlin Lei, Yigong Shi (2019). Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177(2): 339-351.

5. Rui Zhou, Guanghui Yang, Xuefei Guo, Qiang Zhou, Jianlin Lei, Yigong Shi (2019). Recognition of the amyloid precursor protein by human γ-secretase. Science, 363(6428): eaaw0930.

6. Xiechao Zhan, Chuangye Yan*, Xiaofeng Zhang, Jianlin Lei, Yigong Shi* (2018). Structure of a human catalytic step I spliceosome. Science, 359(6375): 537-545. (*co-corresponding authors)

7. Rui Bai, Ruixue Wan, Chuangye Yan, Jianlin Lei, Yigong Shi (2018). Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation. Science, 360(6396): 1423-1429.

8. Xiaofeng Zhang, Chuangye Yan*, Jing Hang, Lorenzo I. Finci, Jianlin Lei, Yigong Shi* (2017). An Atomic Structure of the Human Spliceosome. Cell, 169(5): 918-929. (*co-corresponding authors)

9. Chuangye Yan, Jing Hang, Ruixue Wan, Min Huang, Catherine C. L. Wong, Yigong Shi (2015). Structure of a yeast spliceosome at 3.6-angstrom resolution. Science, 349(6253): 1182-1191.  

10. Peilong Lu, Xiao-chen Bai, Dan Ma, Tian Xie, Chuangye Yan, Linfeng Sun, Guanghui Yang, Yanyu Zhao, Rui Zhou, Sjors H. W. Scheres* & Yigong Shi* (2014). Three-dimensional structure of human γ-secretase. Nature, 512(7513): 166-170. (*co-corresponding authors)